A very simple, minor one.
Let me fast-travel when I'm over-encumbered, dammit!
Look, carry limits make a lot of sense in a lot of games. They're typically there to keep you from hoarding resources that are meant to be scarce (System Shock 2, Dead Space), from having an obscene amount of options to choose from in combat scenarios (The Elder Scrolls, Fallout 3 and New Vegas), or a combination of both. Its meant to keep you from being overpowered, and thats fair. But guess what, Bethesda? Guess what, Obsidian? I'm going to hoard everything I find in my personal hideout. I'm just that type of player, I use all the resources at my disposal. You can make surprisingly profitable transactions in Fallout: New Vegas with a bunch of silverware, office supplies and ruined books. Thats just how I am, I can't turn that switch in my brain off when a game allows that option. Just let me hoard in peace. You want to slow my character fine for combat and stuff, fine, but don't make it so I have to make multiple fast travel trips just to get all the loot. I'm going to do it anyways, so just give me a break, please?