Dude, there's so many awesome games coming out, for me I'm sure I'll play about 10-11 games and these are pretty much triple A titles all... Below are the ones I'll definitely play (with the possible exception of the last two) in order of my excitement for them, although note that a LOT of them are quite close.
1. Elder Scrolls: Skyrim - my favourite game franchise ever
2. Star Wars: The Old Republic - really awesome game (honestly, never been so excited for an MMO) + MMO to tide me over game droughts
3. Assassin's Creed: Brotherhood (+AC3 if it makes it to 2011 for the PC, but I doubt it) - I'm a sucker for stealth games and the AC franchise is one of the best and most innovative among them
4. Mass Effect 3 - it's fucking Mass Effect, the fact it's not first on the list just tells you how crazy I am for everything above this point
5. Dragon Age 2 - loved Origins, almost as excited for DA2 as I am for ME3
6. Batman: Arkham City - once again, I can't believe a game this good is so far down on my list and again, sucker for stealth games, Asylum did an amazing job with it
7. Deus Ex: Human Revolution - couldn't be arsed with previous games (I know, I'm a horrible human being) due to how old they are, but this is looking pretty amazing
8. Portal 2 - amazing that a Portal game can end up this low, especially considering it'll have co-op I'm really anxious for to play with my mate, but I just can't compare a puzzle platformer with the above games
9. Shogun 2: Total War - Total War bringing it home... I'm not much for strategy games, but like the turn based ones and I loved Rome, this should fulfill my strategy needs
10. The Witcher 2: Assassins of Kings - not a fan of the first game, but if they rework the combat/camera just a bit, I'll definitely play it, hoping they will due to the added stealth elements and such