Oh dear... Uh, let's see. This isn't in order at all.
I can't decide between:
Mass Effect 3 - Because the Reapers are attacking Earth. I like that direction, it might make it slightly more hectic if you know that the longer you take, the more people will die (like the end of ME2).
Resistance 3 - I'm an Insomniac fan. This one both looks great and is going back to the strengths oif the first and keeping with the greatness of the second while steering it in a darker direction.
Crysis 2 - written by Richard K Morgan? Oh dear God I hope EA doesn't fuck him over...
Duke Nukem Forever - I've played it, it's freaking awesome.
Deus Ex: Human Revolution - I've watched this one being played and it hinestly stays true to the originals freedom, and looks absoultely stunning with one hell of a refreshingly new atmosphere and vibe to it.
EDIT: Can't believe I forgot Portal 2!!! For obvious reasons it gets to be in the most anticipated list
Honorable Mentions
Elder Scrolls 5 - Obvious reasons. Though I myself don't plan on buying it. Only because my net is capped and shittily slow, therefore I will wait for the GOTY edition the following year with all the DLC and patches.
Mirror's Edge 2 - I'm hoping for this. But I doubt it will come around anytime soon...
Dead Space 2 - While it will be great, I think the others will be better.
Uncharted 3 - So far it looks like it'll be the weaker one... I love the setting, but something abouut Drake looks wrong and the name is a little average...