Exploders in Dead Space, especially on Impossible difficulty, where they're pretty much a guaranteed one-hit-kill. So, if you've got a bunch coming at you from different directions, you're basically fucked over and over again until you get lucky. I'm also none too fond of the Divider parts, which will invariably end up wasting a good chunk of my ammo and jumping at me at least once. The heads especially freak me out, since they're basically out to body-jack you (and they'll definitely succeed on Impossible, even if you have almost full health, 'cause they're just dicks like that).
Then there's the colossi in Shadow of the Colossus. Great game, but I don't think I've ever sworn so much in my life.
Then there's the colossi in Shadow of the Colossus. Great game, but I don't think I've ever sworn so much in my life.