As a duely-appointed Enclave commander, I feel it is my duty to instruct you in the ways of the Vault setup. When setting up your Vault, here are some ideas to stick to in case you come up dry.
{1} You shove a whole bunch of scientists into a place deep underground and tell 'em it's called Black Mesa... Then, you surround them with dubious lab equipment and flood the place with mutations once some wet-behind-the-ears nobody in an armored suit screws up a lab experiment... And this is how they record episodes for Freeman's Mind.
{2} Build it inside of the San Andreas faultline, claiming that the Vault is completely earthquake proof. However, while this is also a lie, you seed their entertainment library with disaster movies like Volcano, Crack In The World, and so on. You tell them they have to stay down there 500 years, just to be sure, and you also weld the door shut.
{3} Secretly transport your people to the Vault entrance without them knowing where exactly they are going. Tell them their Vault is in New Jersey, and that there's no time to lose. Quickly shove some map references and instructional kits to stay down there for about a hundred years. They will be prepared for anything in New Jersey...but it'll be Canada!
{4} Another media disaster one. Fill their entertainment library with nothing but science fiction, bad or otherwise. Make sure to include anything about zombies, nuclear disaster, the end of the world, and give them 800 copies of the Zombie Survival Guide. Then, after a mere two centuries, pop the lid and see what happens...
{5} Finally, Project Vice. In the bottom level of the Vault is a creature in stasis which is vicious, regenerative, and can even take a human form. It is incurably evil, produces all sorts of volitile elements and compounds in its body, and its container is incapable of being destroyed. The timing mechanism malfunctions and releases it three years in. Have fun!