1. get a fat man and don't be afraid to use it.
2. don't finish main quest without Broken Steel
3. spend most caps on ammo and stimpaks
4. don't finish main quest without Broken Steel
5. Do 'Power Of Atom' quest first chance given
6. don't finish main quest without Broken Steel
7. keep a melee or unarmed weapon (depending on your skills) at all times and use them on weaker foe, like Radroachs, Mole-rats, weakly-armed Raiders, etc.
8. don't finish main quest without Broken Steel
9. Kill Smiling Jack at Evergreen mills and take his Terrible Shotgun.
10. don't finish main quest without Broken Steel
11. complete optional quests in 'Wasteland Survivor Guide' mission.
12. don't finish main quest without Broken Steel
13. (Optional) take Good route and recruit Fawkes when possible.
14. don't finish main quest without Broken Steel.
edit: yeah, I'm very serious about not completing the main quest without Broken Steel, and for good reason.