Grand Theft Auto + Three-Leaf Clover = RAGE
Strangely enough, it's now one of my easiest missions.
I originally raged because I had made it all the way to the end, didn't think to rush out the top, then was bombarded. Second time - Made it to the SUV out front, NPC got lodged in the environment, busted by police.
Third time - Made it out of reticle, finger slipped, fired weapon, caught by police, flipped car, death.
Likewise for the final mission, the game froze as Niko got into the helicopter.
I'm sure there were instances in San Andreas as well, but I cannot remember them.