Dark Souls is great. I've made 4 different files, all of them NG+1 at least, planning a fifth.
I've replayed the Jak and Daxter, Ratchet and Clank, and Sly Cooper trilogies countless times.
Same with the first three Spyro games.
I love Final Fantasies 6 and 9 and have played them both a bunch accordingly.
Resident Evil 4 I have played a lot as well.
I'd play more Vampire: the Masquerade Bloodlines (I've made 5 files) if it weren't for the fact that I'm a huge wimp and the Oceanview Hotel (that's what it's called right) is a mandatory part of the storyline. I know how to do it, where to go, and what to pick up and everything. It's just the idea of turning a corner and the axe murderer standing right fucking there and then disappearing just as you freak the hell out. Funny thing is, other than the required run-in with him (where you see his feet moving behind some pipes), there are times where I don't even encounter him and I'm still paranoid to start a new file again.