The quality of something does not depend on its target audience as much as it relies upon its overall dedication and soul. Many of the things you mentioned are generic money-grubbing products dressed up in pink to appeal to girls. However, all this does is overload the market with crap (often that crap is well-received, but people are idiots, so...) and offend those girls who are smart enough to realize that they are being pandered to. Still, if it has heart, vision, and a dedication to quality, rather than a get-rich-quick mentality, or an attitude of talking down to the audience, then it can be good. For instance, Powerpuff Girls was great. Remember when the mayor killed Navi? That was great.