From 160m quid, I'd probably invest 150m of to become a patron of technology. Maybe establish a faculty of genetics in a university somewhere, where the profits from therapies developed are reinvested into the school and staff to attract the best and brightest, as well as keeping it as self-sufficient as possible.
With the remaining 11m, I'd ensure my parents have the retirement they always wanted, my sister and my nephew's future guaranteed (I'd give them a base-salary allowance for 20yrs, meaning that if they wanted more than the minimum, they'd still need to work hard), and my son's future is safe (he has a rare condition and will likely require treatment all his life). Probably buy land in a remote yet fibre-optically covered area of Scotland somewhere and let my survivalist leanings take over - I'd need to stay lean and Spartan because my Scorpio character loves to indulge.
But Sparta aside, holy shit can you imagine the LAN parties ?!?!!!