Most Kickass shotgun.

[Banana Phone Man]

HL2s SPAS 12 is killer. I like MW2 one as well but their duel Winchester 1887s are very efficiant for the job.

 

[Segadroid]

Sawn-off shotgun in GTA IV: The Lost And Dammed

 

[dekkarax]

The shotgun in worms.

It does as much damage as a bazooka.

 

[General Ken8]

I'd say the hydra from RE5
A triple barreled sawed-off shotgun that probably eats kittens and rainbows for breakfast

 

[theSovietConnection]

Six men came to kill me one time. And the best of 'em carried this. It's a Callahan full-bore auto-lock. Customized trigger, double cartridge thorough gauge. It is my very favorite gun... This the best gun made by man. It has extreme sentimental value...

I Call It Vera.

 

[ultracheeser]

I love the Lost Planet and Halo shotgun.

Most of all though Electric and Exploding bullets always win via Bioshock.

I'm with on the Bioshock shotgun, but Halo? What the fuck? that thing was accurate from point blank to five feet. I hated that thing.

 

[KissofKetchup]

JACKHAMMER!

If you're referring to the Pancor Jackhammer, the bullpup fully automatic shotgun, then sorry to burst your bubble, but that gun was only a prototype and never went into production...
But I think you'd agree that the AA-12 is just as awesome, even though it doesn't look as cool.

 

[True Nero]

i'm a fan of the striker from RE4.

rapid fire and 100 shot drum

 

[Earthbound Engineer]

Hands down, the most badass shotgun in existence is the Marauder Shotgun from Red Faction Guerrilla.

This thing was constructed out of all things evil and cool.

 

[Shurikens and Lightning]

The shotgun in L4D2 that has the handlebar and is black. Its the same one from killzone 2.

 

[Wintermoot]

the SPAS12 from the HLS HD pack mod just awesome or the Rosebox Terminator 2 shot gun

 

[Ph33nix]

realife AA-12

games: the halflife 2 shotgun when you set it to shoot over 10000 pellets per shot.

 

[AlchemistMayCry]

The Hydra from Resident Evil 5 (Triple barreled sawn-off shotty? Send it to Bruce Campbell.) and the Terrible Shotgun from Fallout 3.

 

[dalek sec]

Just the Spaz-12 in general, something about it I just love.

 

[UnearthedArcana]

The Remington 870 from Black, also known as 'how you open doors'.

I also love the Homeland .37 from Far Cry 2. I know the USAS is more powerful and has a higher rate of fire, but the manual action on the .37 makes for a more intense firefight. For the same reason, I only use the bolt-action sniper instead of the SVD and the 50 Cal (the bolt-action also has a better scope than the SVD).

It's just more fun when every shot counts.

 

[slipknot4]

Any shotgun from Borderlands that causes electric explosions.

 

[brodie21]

the spas 12 with silencer in MW2

 

[NathanAjax]

The Shotgun from GoW was pure win in multiplayer. And the Pistole from Uncharted 2 was the most badass weapon in the game.

Spoiler

 

[Ph33nix]

Six men came to kill me one time. And the best of 'em carried this. It's a Callahan full-bore auto-lock. Customized trigger, double cartridge thorough gauge. It is my very favorite gun... This the best gun made by man. It has extreme sentimental value...

I Call It Vera.

you sir get a plus 30 awesomeness for the firefly reference.

 

[Scorch_Phoenix]

Benelli Super Nova Tact.
or
Benelli M4

also that shotgun from Resident Evil Nemsis you get from killing him and getting all the parts.

http://residentevil.wikia.com/STI_Eagle_6.0

Doesn't look like a shotgun to me