Short answer: No
Long Answer: No because I can't see VATS working and the fact that you can kill or save anyone doesn't work in a two player environment. If some one were to come and join my game when I'd already done a quest that involved doing something similar to blowing up Megaton but they hadn't, then what do they do? Your personal actions have too much of an effect on the wider world to incorporate two players. Unless, it is done in a similar way to Fable 2 multiplayer, I don't see it working.
Also, part of the joy is traversing the wasteland and having that feeling of being truely alone in a strange place until a death claw comes and rips your spine out and beats you to death with it. Although, I understand that New Vegas will be a lot less barren, I can only assume that there will be a large portion of wasteland.
Long Answer: No because I can't see VATS working and the fact that you can kill or save anyone doesn't work in a two player environment. If some one were to come and join my game when I'd already done a quest that involved doing something similar to blowing up Megaton but they hadn't, then what do they do? Your personal actions have too much of an effect on the wider world to incorporate two players. Unless, it is done in a similar way to Fable 2 multiplayer, I don't see it working.
Also, part of the joy is traversing the wasteland and having that feeling of being truely alone in a strange place until a death claw comes and rips your spine out and beats you to death with it. Although, I understand that New Vegas will be a lot less barren, I can only assume that there will be a large portion of wasteland.