This isn't any particular plot point, but it happened to me after finishing the last quest of Broken Steel, Who Dares Wins. I had played as an evil character the entire game, so needless to say I took the evil option at the end of the quest. Without spoiling anything, it's an absolutely MASSIVE, completely pointless dick move, the reward of which is thousands of caps worth of equipment, including two tesla cannons and a very good custom pistol, as well as the total hostility of the brotherhood of steel. Anyway, I realized after making it back to the citadel at the end of the quest and dealing with the enemies there that despite my huge material wealth and deadly combat skills, my character was totally alone. He had killed so many potential friends and every reliable weapon merchant, save lucky harith. As I was realizing that being a dick got my character nowhere, that song "Happy Times" started playing on the radio. I nearly cried.