MGS4
The Witcher 2
The Witcher
Big Boss´ death, Raiden´s reunion with Rosemary and his son, the microwave tunnel, EVA´s death. that game made me weep like a child.
The Witcher 2
when you kill Letho. he never really meant harm, he just wanted to rebuild The School of the Viper and the only way he could do this was to earn money by killing Kings (most of the Northern Kings are massive assholes, so i really didn´t mind). he looked like a complete oaf, but he was clever as hell and really had a good cause behind his actions.
The Witcher
the ending... just WOW. that twist is something i have never seen another developer do.