'Shut up!'

[SangRahl]

"Snake. Snake? SNAAAAAAAAKE!!!"
Yeah, they spotted me and I got killed. They know it, you know it, I sure as hell know it... Please stop yelling into the bloody earpiece, ferchrisakes.

"That's a nice head you have on your shoulders." (old-school Governator accent)
Every single sea raider band we track down (or catches us, if not prepared for them) seems to bellow this at the parley screen... Funny thing is the typed text on the same screen: "I will drink from your skull!"

 

[bulldogftw]

"Stop you violated the law", you knew it was coming.

 

[silver wolf009]

"Are you sleeping or what?"

Metro 2033.

 

[Jroo wuz heer]

"Hero your will energy is low, watch that"
"Your health is low. Do you have any potions or food?"

fable 2 actually referenced how annoying that was in a loading screen. say what you will about fable 2, but it is damn funny

OT: anything sargeant johnson says during combat in halo 3

 

[BanthaFodder]

not an NPC, buuuuuuuut....
*Squirtle's health drops to 5 HP*
me: "oh shit, his health is low, I better-"
game: "WEEE-WOOO WEEE-WOOO WEEE-WOOO"
I mean, yeah, if you're playing againsta friend or a gym or the elite 4, it makes things seem more hectic, but if I'm walking through the tall grass to get to a pokemon center, then I'm jumped by a level 2 Metapod, I don't need a frigging siren alerting me I'm so close to fucking dying.

 

[steph01a]

from Morrowind: Guard to PC - "Someone with your good looks needs more clothing"

 

[JUMBO PALACE]

What's he doing up there?!!

-Every Assassin's Creed game.

 

[SomethingUnrelated]

Need I say more?

FUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU-

I had heard stories... But I had never guessed it was that goddamn awful.

She's not. It's one of countless examples of how people greatly exaggerate the frequency of Navi's "Hey Listen" line. Maybe they changed it for the Collector's Edition, but my Navi only pipes up when I've not done anything significant for several minutes.

Ah, yeah. Probably ought to have considered that the video wasn't really in context all that much.

 

[badgersprite]

Vanille: "*giggle* I'm tougher than you thought, huh?"

Me: *Murderous eyetwitch...*

 

[Thy Doctor]

YOU SHOULD OF PAID THE FINES

 

[jpoon]

She's not an NPC, per say, but omg Sarah from Star Ocean. I want to reach in the game and punch her every time she says ANYTHING.

<youtube=kuWHXGjnkNc>

SHUT UP SHUT UP SHUT UPPPPP

Good god, i fucking hated that game. Never again will I fall for a Star Ocean game.

 

[pyrosaw]

Reload Dr. Freeman!

 

[King Kupofried]

Not so much a phrase as a noise. From Dragon Age, Bards, their songs.
I don't know, maybe I'm just uncultured, maybe I don't understand Bards. I'm fairly certain throwing your arms back and yelling "HUAAAAAAAAAAAAAAAAAAAAH!!" like you are charging up some DBZ super move isn't really the kind of singing anyone expected. There were plenty of sound effects in the game that could have substituted for what could reasonably be an indication of a Bard song activating, it could have made no sound at all it would still be less weird.
I'm not really sure I know why it bothered me as much as it did, but I just could never get over it. I would even make the effort to remove my headphones every time I was forced to activate a song simply because I would dramatically cringe every time I had to listen to it.

 

[Buzz Killington_v1legacy]

From the original Diablo: "I sense a soul in search of answers." Yes, you annoying woman, this is the thirty-seventh time we've met. Your seer act is no longer impressive. Now let me me shop before I turn your head into a festive hat.

 

[Cheery Lunatic]

Everyone in Assassin's Creed II. Everyone.
It got so bad that I just muted the game, turned on subtitles, and got out my iPod.

Of course, this was a double edged sword as I couldn't tell when guards/archers were yelling at me to get off roofs.

 

[JdaS]

I always played Shantotto in Dissidia, and when fighting my friends, I would often use Bind. Unfortunately, that meant hearing the voice actress every freaking time I used the spell.

"Seriously? Seriously? Seriously? Seriously? Seriously? Seriously? Seriously? Seriously? Seriously? Seriously? Seriously? Seriously? Seriously? "

Sounds more like dubbed Hakan from SSFIV to me. "Seriously!? Seriously!? Seriously!? Seriously!? You'll pay! You'll pay! You'll pay! Seriously!?"

 

[Doctor Glocktor]

GET GABBIN OR GET GOIN'

Seriously, STOP STAYING THAT.

 

[Megacherv]

Leader of the Reapers in Just Cause 2

ComRAID

ARGHHFGHLUGFGKSHIULGSKYTFCKYHLIU:GFergdfryui67S*Oadueyt43x[o\piy

Rage over...

EDIT: "Ramirez, do everything!"