Lara Croft: A character who was made for nothing but sex appeal, which may have been okay when we had like NO female characters in games, but today that doesn't cut, it.
Tommy from Prey: Already been said, which makes sense. He's an idiot with no personality and a lame haircut, and whines about everything eventhough he thinks he's a badass. It's actually kinda funny, coming from the company thet designed one of the biggest badasses ever (What? I think Duke's awesome...)
Liu Kang: Midway, I know he's always been your established hero, but please: PRACTICALLY NOBODY LIKES HIM. He's a stereotypical action character with moves that are used in most fighting games (Fireball, Uppercut, special kicking move.) Please: Make a Mortal Kombat game starring Scorpion or Sub Zero: almost everyone likes them, or atl least finds them fun.
Sakura from Street Fighter: Face it Capcom: nobody likes your anime schoolgirl wet dream but you. The only reason I played as her is to unlock Dan Hibiki, who is obviously the best character out of anything of all time, and even then I skipped her cutscenes and turned the volume alomst all the way down so I didn't have to hear her. And I set it to 1 round matches on the easiest difficulty, just so I didn't have to deal with her boring copypasted moves and annoying voice acting as long.
Hannah Montanna: There was a Hannah Montanna game, so this can be here. Way to make a good role model for kids, Disney, telling them to disrespect parents and be a spoiled brat to everyone. If Walt were here, he'd uppercut whoever brought her on the air into the sun.
My Xbox Live Avatar: I don't care if he's in strong likeness to one of the most awesome characters ever (Doom Marine), having to watch that monstrosity wal around the screen disgusts me.
Zoey from L4D: I guess not really her, just her voice actor. I've had to deal with her in all of the Halo games, Doom 3: Ressurection of Evil (which rhymes with reprecussions of evil, I have no idea if that's on purpose), F.E.A.R.2 (which couldn't have sucked mre anyways), and a whole bunch of other games.