Lost Odyssey.
Seriously man, that game is motherfuckin' solid. It's the only game that I literally can't progress in. Random encounters take way too much HP out of you, HP items are too rare, and the boss fights are just stupid.
Seriously. Do not buy it. You will die in real life. The seemingly-above-average-so-far story is definitely not worth the stress this game will give you.
Jesus. I'm only on the second or third boss fight (that big worm dude that spawns loads of enemies and obliterates you with that nasty-ass laser if you spend any time attacking him like you're supposed to instead of his friends, and even if you do kill everything he spawns he respawns more and uses that apocalyptic-ass laser anyway), and I actually can't do it. I got just past the part where he revives himself (yes, he revives himself after by some act of divine help you kill him once, and in the same fight, so you have no chance to rest), and by that point one of my characters was dead, I had no reviving items left, also had no healing items left, and my other two characters were very, very low on health. His spawns finished me as soon as he revived and spawned some more.
I'd killed every single enemy I'd encountered along the way to level up so there was no reason for him to be so much stronger than me. Hell, the random encounters on that game are equivalent of about three quarters of the difficulty of an early boss fight on a normal JRPG, and they're about as common as random encounters on a normal JRPG too.
Also, Enclave. At least, I did give up on it until I got some cheats for it. You play as one character in levels full of, on average, roughly, about 30 or so computer-controlled enemies in that you meet and fight as you go through, as with most games. The number is a complete guess and I'm probably wrong but yeah. That would be fine, except that every one of these enemies is approximately as strong as you. So killing even one of those enemies is a serious achievement. The next one will likely finish you off.
It was when I was about 11 that I last played Enclave without cheats on, but even the reviews all say that Enclave's difficulty is insane.
But once you turn God Mode on, it's not a bad game. The story's not too bad. They were supposed to make a sequel which would have been nice (if they toned down the difficulty) but they stopped it. It's a pity.