DRM II will come out, and force you to stick a genetically modified jellyfish up your ass before your are allowed to play the game.
Alan Wake will get delayed, again.
Jagged Alliance 3 will change developer again, and they decide to change it into a first person shooter instead.
Heavy Rain will require a £5000 computer from the future to run smoothly, and still have crappy controls that make it feel like a console port.
Half Life 2: Episode 3 gets delayed into the next century as Valve decides to introduce a 1000 dimensional anti gravity physics engine along with it.
Dawn of War II will be the most unbalanced RTS game ever. As the fastest stealth faction dominates by teleporting everywhere and capping the entire map; and one faction will has some doom fortress that costs nothing at all, but is effectively invincible. As a result Relic is bought by EA games, who then announces they will make Company of Heroes 2 a dumbed down fantasy WWII action game featuring bikini girls with huge tits carrying mini guns.
Hearts of Iron III will be a mess of bugs, and have no AI.
Empires: Total War won't run on my Quad core, 4GB RAM, 8800GTX monolith of 2007.
All FPS games will be about space marines shooting aliens or set in WWII (COD:MW2 will be delayed 'till early Dec at least). All third person shooters will have crappy controls on the PC ported directly from the consoles.
If all of the above happens, I'll give up PC gaming, buy a PS3, and join the Metal Gear Solid, Gran Tourismo, and Final Fantasy fanboy clubs.
Edit: just realised Heavy Rain is PS3 exclusive.....