This is an obscure one: The Thursday Next Series by Jasper Fforde.
Ok, here' the deal: All those characters in literature? When you're not reading their books, their actual people that can think for themselves, and live their own lives... to a degree. They're also aware that they're in books, and treat their readings as if they were acting out scene from a movie again and again.
Now, take that premise, add in time travel, genetic manipulation, great action sequences, and some of the best British Humor since Monty Python, and you have a great series of books, and a great premise for, if not a movie, at least a TV serial.
Seriously. Read them.