The announcement of an M-Rated game based upon the Blacksad series of graphic novels might be the only thing that even comes close to causing any of my sphincter seals to break. It'd be like L.A. Noire, only furrier.
I'd do a lot more than lose control of my bowels if something as completely crazy as an AO-rated Leisure Suit Larry style adventure game release of an adaptation of Fritz the Cat, Fabulous Furry Freak Brothers, Wonder Warthog or Skunk Works would be announced at E3.
I'm pretty sure that everyone at E3 would as well, only to an even more severe extent. Now that's what you call a shocking announcement!
Everything else, even a Shantae game on a console, would, at most, elicit a hearty "Good for them. Good for Me. Good for Gaming." sentiment out of me.