I tend to switch it up. Sticking to one party's going to mean you're not going to be good at the rest. Meaning, when you actually need a different party, you're going to be shit with them.
I usually pick the team depending on what mission i'm going on, and decide which ones fits best to the mission. But I believe I always use Miranda and Garrus/Thane. Miranda's extra damage combined with Garrus's/Thanes sniper rifle is a great combination. Miranda up close, me in the middle and Than/Garrus in the back
Jack and Grunt. I love them so much, that I don't think that I will enjoy ME3 as much, if I can't use them in my party. It would kind of ruin my experience.
I found myself using Garrus and Mordin a lot. Mostly because Garrus had overload and Mordin had incinerate, which was always a good combo. Plus they were some of the best characters.
In ME1 I always had Ashley and Garrus, can't wait to do it again in ME3!
I always stuck to Miranda and Garrus, they worked well for me. In Mass Effect 1 my team consisted of Garrus and Wrex. I hope I can recruit Wrex next game.
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