Large spoilers in this post
After playing the game, I'm in two minds over where the next one will be set. It would be understandable to put the game in the "present day" (although we are not told at what time Desmond is actually living). With the information that the templars are only a minor problem compared to the solar flares that are happening in desmond's time, as well as the fact that Desmond is now a fully trained Assassin, means that the present time is probably where Ubisoft will go. However the present would mean the introduction of guns, and with it the need to completely overhaul the combat system from that of the first two games (I'd consider that a good thing

). Swordfights would be out, gun combat would be in. Perhaps the game would have to be more stealth orientated.
Then again, there is the chance that for some arbitrary reason Desmond could be put back in the animus and put in a different location. I remember one of the Ubisoft devs saying that they could make a hundred Screed games all in different locations if they wanted. As long as guns weren't introduced, there would be little to change to the basic system of the previous games. I think that's a great idea.
Of course the problem with that would be that there would be too little gameplay innovation from Screed 2, so the game would get panned by critics. With the need for new gameplay, it would make the most sense to go to the present day, with freerunning, and the new gameplay innovations would take in to account guns.
Personally I think that would be awful. I love the Screed games (both of them) for their immersion in the past, the concepts of free running and hiding in plain sight, and the realistic feel to the cities. I hate Desmond's back story, since its far too silly with all its conspiracy theories and forerunner ideas. Is playing the characters in the animus not enough? I don't think the over-arching story is that necessary.
So basically I would like to see it set in another interesting part of history. Roman empire would be awesome, so would fuedal japan. Of course Screed 2 was supposed to be set in Revolutionary France...now thats an idea
