-Master Chief- All of his fellow Spartans, who were like his brothers and sisters, most of them died on Reach. That's gotta be a suckerpunch right there, and at some point the other Spartans die too. So.....sucks for him.
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-Altair- He was basically the second in command of the Assassins and through one poor choice, he lost it all, then finds out that his leader is a psychopath, bent on ruling the Holy Land.
-Left 4 Dead People- This doesn't need to be explained. Being vomited on by a person is one thing, but by a fat zombie whose puke makes other zombies come to you? Along with being strangled, mauled, crushed, and flipped out on. (Boomer,Smoker,Hunter,Tank,Witch)
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-Main Character from Bioshock- His plane crashes in the Atlantic, Pacific, wherever. He gets down into Rapture, goes through hell working for Atlas, then for a...disturbed...artist.....person. Then when you finally take down the *bad guy*, you find out that you are being mind controlled. Then you have to kill the guy who was *helping* you. Oh, and while you're doing this, you're fighting off sentry bots, machine gun toting nutjobs, splicers, and Big Daddys. And the only ending worth getting is too much trouble for, since you don't get enough Adam to get every upgrade at the gathering garden.