Upon reflection, the only vidya game characters I'd find remotely date-worthy aren't villains. The rest are so fucked in the head it would probably end up on the whole praying-mantis mating cycle, mainly ending with myself dead in some horrible fashion. Also as a villain myself, I don't fish in the company pool. I honestly can't think of a female villain that would be even close to my dating prefs in video game worlds. Going with video-game/comic crossovers I'd probably settle on Mystique from the X-Men universe.