After playing this for hours, and beating it twice, ive had my fair share of WTF moments.
One time, when I was playing, I did vats literally on top of a super mutant behemoth in evergreen mills. I shot it in the head, and the head exploded. yay. But as I was walking, I noticed, chunks of the head, were on top of me. It wouldn't go away. There was this giant brain piece, stuck to my character's face. it was weird. it went away next time I loaded the game. In megaton, I went to a crevasse, and got stuck in like this pale grey box in which I couldn't move from. I have the ps3 port, which is pretty glitchy. Also, one time, the whole world was only half rendered, I couldn't see any textures, it was weird. so I reloaded the game.
Also, I met an enclave soldier by dukovs place. I was only level 8. But I beat them. (used almost all my stimpacks though).
those are only a few of the glitches I've seen. There are others, but theyre not really that interesting, like how one of the megaton settler always answers hi, every time I talk to her, unlike every other settler, who have SOME variation.