"Severin, I have bowel in my hair!" - Rayne, BloodRayne 2
"You know what they say: 'To save the world, you have to push a few old ladies down the stairs.'" - Bernard, Day Of The Tentacle
"Who was that? Wait, don't tell me, evil wizard. They all sound like Richard III on crack to me." - April Ryan, The Longest Journey
"Greetin's, I have some questions... can ye tell me about this place? Who's the Lady o' Pain? I'm lookin' fer the Magic Girdle o' Swank Iron, have ye seen it? Do ye know where a portal ta the 2,817th Plane o' the Abyss might be? Do ye know where the Holy Flamin' Frost-Brand Gronk-Slayin' Vorpal Hammer o' Woundin' an' Returnin' an' Shootin'-Lightnin'-Out-Yer-Bum is?" - Elderly Hive Dweller, Planescape: Torment
"STOP POKING ME!" - Orc Peon, Warcraft II
"Weapon statistics hanging in the air, glimpsed out of the corner of my eye. Endless repetition of the act of shooting, time slowing down to show off my moves. The paranoid feel of someone controlling my every step. I was in a computer game." - Max Payne, Max Payne
"That night...I was trying to make you a great warrior!"
"You succeeded." *splortch* - No citation needed.
Also, anything that Minsc says. The man (and hamster) is comedy gold.