Metal Gear Solid 2- "Change sides? I don't remember saying I was on yours."
MGS4- "It's all so FUCKING hilarious!" (This one's mostly context- it's incredibly creepy, since it's being said by a chronically laughing sociopathic woman in a mechanical octopus hat)
Bioshock- "Atlas, Ryan... Atlas, Ryan... Let them have their squabble. The artist, yes, the artist knows there is richer earth to till. When I am dust, this is what they'll point to: My masterpiece! Go ahead... Don't be afraid. Touch it. What's that look? You don't like it, do you? Well, I don't need to be judged by you- by anyone! Screw you! Screw all you fucking doubters! I'm Sander Fucking Cohen!"
Pokemon Ruby/ Sapphire: "All dreams are but another reality. Never forget..."
Portal- "All Aperture technologies remain safely operational up to 4000 degrees Kelvin. Rest assured that there is absolutely no chance of a dangerous equipment malfunction prior to your victory candescence." (See also: everything else GlaDOS says)