Gordon Freeman, but he doesnt speak much.... and he is holding a crowbar....
Also it could be Jade from Beyond Good & Evil..... Now thats a smart, hot girl...
And for Last Solid Snake MGS3.... finnaly someone that can speak, has a sense of humour and knows millions of storys to entertain... i just.. wait.. where is he? and whats that strange cardboard box doing in the corner of my living room!?