Europa Universalis: Heir to the Throne is made to piss a person off.
Playing as Rajputana, I had managed to unite all of India except two small vassals and the Maldives. My infamy was stupid high, so I decided to cool down a little while I adjusted the sliders towards centralization and innovative to Westernize. I spread a few colonies out into the Philippines and Africa. Everyone was going great. I finally had some brat heir with the needed seven admin so I wouldn't remain a backwards nation forever, my stability hit three. It was going to be a cakewalk.
Then I was hit by several -stability events and my country spiraled into a twenty year civil war. Every couple of minutes I would get another nationalist revolution event and 3 to 16 more rebel units would pop up somewhere on the map. Assam, Delhi, Kashmir, Bihar, Maharashtra, Vijayanagara, Bengal, Nepal, and Bhutan all managed to declare independence at one point or another before I finally managed to contain the last few pretender armies in what was Bhutan. But to do this I had to lose a point in centralization and innovation. The heir died of disease, and Spain annexed my African colonies(I was only gaining .1 colonies per year anyway,) cutting me off from Westernizing for the moment beyond Muslim technology.
I was fucking pissed.
Then there's trying to create Germany inside the bounds of the Holy Roman Empire. +4.5 infamy a year because I illegally occupy imperial territory? 150 infamy. Goddammit.
Or playing one of the new world Indian nations. Spending the entire game trying to hold together your empire, and having the Spanish suddenly declare war and insta-annex every province they touch while their 3000 man army routs your 20,000 strong army.