The first time i saw a mirelurk coming out of the river to the right of me i literally jumped. But really all of them have their little weakness.
Ant, and fire Ants - just shoot a couple of their antenna in VATS and let them fight between themselves
Deathclaw - dart gun
radscorpion + mirelurks - i normally just run around in a circle, make it chase me and let my follower kill it, but if not the backwards run and gun does them nicely so long as your legs aren't crippled.
Ghouls - ghoul mask. priceless. failing that, shotgun (terrible for preference) to the head in VATS sorts them out sharpish
Super mutant behemoths - a big fuck load of ammo + somewhere to hide, small doorway and the like.
Ant, and fire Ants - just shoot a couple of their antenna in VATS and let them fight between themselves
Deathclaw - dart gun
radscorpion + mirelurks - i normally just run around in a circle, make it chase me and let my follower kill it, but if not the backwards run and gun does them nicely so long as your legs aren't crippled.
Ghouls - ghoul mask. priceless. failing that, shotgun (terrible for preference) to the head in VATS sorts them out sharpish
Super mutant behemoths - a big fuck load of ammo + somewhere to hide, small doorway and the like.