Clearly, the most interesting thing that could make sense given what we know (and assuming it doesn't get tied up in the 3rd game) is the impending Quarian-Geth war. Maybe we get to follow a young Quarian being sent out on pilgramage and finds technology/information that could be key in defeating the Geth.
Other than that, I'd like to get a look at the workings of the larger military-political organizations. Be it a high-ranking Turian or Alliance member (and preferably one who commands a dreadnought).
Other than that, I'd like to get a look at the workings of the larger military-political organizations. Be it a high-ranking Turian or Alliance member (and preferably one who commands a dreadnought).