I said no, but for a fairly specific reason. Basically, we've already had the U.S. government as the enemy in a number of movies, and frankly, it's boring. Someone has to be stupidly evil for any of it to make sense, as the majority of the bureaucracy isn't set up for that sort of thing.
Now, as for the U.S. being the enemy while well outside the U.S., in some little war-torn nation, maybe that could be done interesting. No one is trying to be evil, and yet they're shooting guns at you anyway, if you're just some rebel that wants the big nation to go away. The problem is, how far can that story arch go? There's really not much chance of winning that one in any sort of straight fight, though a thief-like string of stealth missions could work. Still, the biggest problem is that one little rebel can't make a big enough difference against the U.S. to resolve any sort of story; it could be interesting to see through the rebel's eyes for awhile, but the story can't end well and still make sense, so there are limitations.
So, I guess the Red Alert series did about as well as anyone can in casting the whole U.S. as an enemy (with frankly loose morals at best to use a time machine). We should probably get over casting Russians and Chinese as enemies though, but I guess I've always been more of a fan of sci-fi and fantasy settings anyway.
