I've had two fail me. The first was my PS2 which happened to a lot of people. Sony made a horrible disc reader and it failed, but at least they redeemed themselves by making the ones after it reliable. My 360 currently has be reset around 20 times to convince it that the disc inside of it is not, in fact, a movie, but a game that a very pissed off gamer wants to play. It's really insulting when the DVD drive in my PC is older than both of these systems and still works.
My NES still works, my Super NES still works, my N64 still works, my PSX still works. Damn quality controls going down hill. It's enough to want to make me just say, "fuck it" and get an emulator.