Nichijou. For those unaware, Nichijou is an ongoing Shonen manga which got a 2 season anime adaption, known for being highly underrated, and costing whatever 123,000 x 26 is, then turning the answer into dollars, then in to yen, yet only selling ~2500 official box sets, which cost about 2,000 yen each. I'm horrible at maths, but that's a pretty negative profit.
It's gained near worldwide fame now for being really good at making GIFs out of (look up Nichijou GIFS. Never before has the term "out of context" been so fitting) and being very very very funny. I'm sure Kyoto would make some money back if they rebooted it, with extra advertising.