Some of the bosses from Dawn of War II come to mind... the Avatar of Khaine, the big Waaaaghboss and the final Hive Tyrant in particular. Ridiculously powerful attacks, and the feeling of accomplishing absolutely nothing as you pump enough ordinance into them to sink a fucking strike cruiser.
Also, the Elder God from Legacy of Kain: Defiance took me forever to bring down. A lot of health, powerful knockdown attacks AND your character also continually loses health due to not getting a bite to drink.
Also, the Elder God from Legacy of Kain: Defiance took me forever to bring down. A lot of health, powerful knockdown attacks AND your character also continually loses health due to not getting a bite to drink.