Are we talking like a centaur arangement or more wolfman-esque? I'm going to assume the last.
While I'd be severely tempted to choose a wolf, I think something like a grizzly bear or gorilla (I'll choose bear) is probably a better choice because they're more similar physically. I'd be taller, stronger and more durable, but with maintaining some aspects like more dextrous digits and my intelligence. Then I'd use my amazing abilities, including enhances senses to be a superhero.
Edit: Actually fuck grizzly bear, I want to be half Polar bear. They're bigger, have cooler abilities and I'd be good at surviving in the snow.
Edit Edit: Actually maybe not, I might overheat in warmer climates...