I think Bioware should make another RPG with a Krogan lead. It would easily be the best way to continue the series, for the following reasons:
1. Imagine how badass a Krogan Spectre is. I mean, it'd take some balls to stand in the way of any Krogan warrior, but you'd have to be a complete moron or the bravest person in the universe to stand against a Krogan Spectre. Playing as one should help the player realize just how notorious this kind of organization can be.
2. You get a lot of history with your character. Krogan can live for around 600-800 years, and they're pretty tough to defeat. That's a lot of gameplay potential.
3. The mercenary appeal. Tied into the prior point a little, Krogan have a history for going merc and wandering the galaxy, taking whatever gun job they need for credits. They're a very violent and very chaotic people. Both of those traits are good for gamers. It justifies constant employer shifts, side changes, and party betrayals.
4. Advanced biotic and combat potential. I don't know how tech can be worked into the game, because we don't know many Krogan that can use tech abilities, but we know that Krogan biotics, Krogan shotguns and the combination of them is feared through the galaxy. There could be some fun combat in this game if it's done right and if the biotics will be something to fear.
5. Player morality. Krogan are a very independent people (this post is starting to remind me just how similar the Krogan are with the original Neanderthals: both are races renowned for their physical strengths, and both are commonly perceived to be nothing more than thuggish brutes, but in fact are highly spiritual peoples), and while there might be that stone cold mentality set in stone (no pun intended), there is potential to act as a paragon Krogan, perhaps become one of the few Krogan that honestly tries to lead by peaceful negotiation.
6. Rachni. You have the ability to survive in their hostile environments, and you should be able to attack them on their own turf for once. It could be an interesting opponent to fight in the game.
7. Adventure. Tied to point 3, but I don't care, this is the most important thing about this idea. Adventure plagues Krogan, and they will always get into some scrap, which is good for the gamer. After all, Mass Effect is all about exploration of the galaxy and searching the unknown. Let's be honest, underneath all the technology, settings, races, timelines, it's the exact same as every other fantasy world out there: go out, explore and conquer. And Krogan are a fine representative of that.
I'd love to see an RPG similar to Mass Effect that centers on a Krogan who becomes a Spectre about halfway through the game, perhaps doing some merc work before then, perhaps running down a notorious criminal or a rogue Spectre after then, and his relationship with the people he meets.
