1. Be confident in yourself, but not all YO ***** SUCK MY DICK. Thats just stupid and insulting.
2. Hygiene. You want to impress someone, you want to make sure you dont smell like a rotting corpse. Wash thoroughly with soap on at least the three key areas (Armpits Arsehole Crotch) and BRUSH YOUR TEETH. Then use deoderant or cologne, but dont swim in the stuff. You dont wanna give chicks a migraine. Comb your hair to suit you, clip your fingernails, have a shave, whatever you need to do to clean yourself up.
3. Dress sensibly. You wanna pick someone up at the local anime convention? Wear a nice FlCl shirt w/ jeans and sneakers. Wanna pick up in a bar? Wear a nice button-up shirt with jeans/good slacks and NO sneakers. Ask a lady-friend or a mate who has good fashion sense what looks good on you. And dont think its faggy to look presentable - its when you start moisturizing your face and getting manicures that you start evolving to that state.
4. Pick a place you know you'll pick up. Going to the library to score a librarian wont always work (unless you work in porn). Go to a bar, nightclub, or even just some community events. Be open to going to new places.
5. BE YOURSELF, but dont overdo it. Dont walk up to a chick and say "hi, my names John, i like anime and computers games." Most 'normal' chicks will balk at that, possibly laugh in your face, ruining your confidence. Simply walk up and say "hey, how you doing? Having a good time?" Strike up a conversation! Ask how she is, what she does for a job, what the weathers been like. It may seem odd, but these topics can bloom into a point where you've gleaned enough info from each other that you can start throwing out test questions to see if you both have something in common. Point:
You: "What do you do for a job?"
Girl: "I work in a beauty salon, in the perfume section."
You: "Oh, do you sell *insert your brand here*? I dont know if its good for me..."
Girl: "Oh, well, i dont sell guy stuff but i can give you some tips if you want..."
Conversation ensues. Try not to force conversation. Let it roll naturally. If you start to feel uncomfortable with the awkward silence, simply say "well, it was nice talking to you", and walk away. If she finds you interesting, she'll try to stop you. Also, don't try to be funny, but slip in a joke or two every now and then. But no 'knock-knock' jokes.
TIP: If in a nightclub, don't be afraid to ask her if she'd like to go someplace more quiet so you can chat. Its usually bloody hard enough to hear stuff in a nightclub.