Clockwork Scarecrow. said:League of Legends.

Oh man, I went into this thread hoping someone would post that League of Legends takes skill, and I have to thank you for making my day. League of Legends is horribly buggy, horribly balanced, and there is very little you can do as a player to set you apart from other players besides knowing what to do, which is usually common snese. The game's "skill shots" would actually be considered skillful if they had accurate hit-boxes and weren't the most spamable abilities in the game.
For reference I play League of Legends daily.
Uh, the last game I played that I'd consider inherently difficult to get good at would have to be either Bloodline Champions or Starcraft II. In Bloodline Champions you need quick reflexes as everything is a "skill shot", including heals. In Starcraft II you need good strategy, reflexes, and game knowledge to succeed.