Like most people here, I wait it out, and if it doesn't go away, I pop a pill. I usually feel fine unless I've been gaming/surfing the web for too long, which I usually only realize when I stop. As a rule of thumb, if I either can't sleep due to the pain or am feeling it for the second night in a row, I take something.
I also usually try to take muscle relaxants rather than painkillers since the relaxants help relief the cause, while painkillers only relieve the syntoms. I think. In reality I may just be trying to justify self-medicating.