Motoko is the best because she will hack your brain. (I'm a massive GitS fan btw.)
Lain because she has already hacked into brain.
No, bad Vorty, need more obscure anime here!
How about Dark Schneider? He's one huge chunk of awesome. Plus there's two exclamation points in Bastard!! Nothing can beat that, right?
No, need something more obscure.
How about Santa? Come on, any guy that carries a whip especially for his cat-girl slave...
On second thought, nevermind that one (Dragon Pink is still the only series that had me falling off my chair laughing).
Ok, I'll settle for something only mildly obscure and one of the best series you haven't seen: El Hazard - The Magnificent World, watch it, it's one of the finest fantasy tales to have ever come from Japanese shores, forget the follow-ups and spin-off series, even though they're still pretty good the original OVA is all you need, don't forget to bring a girl for the last episode.
Ifurita - This nigh indestructable ancient demon god weapon was made to destroy worlds and is capable of copying any attack that's been used against her. She comes equipped with a luscious body, is packaged in an amazingly roundabout designed tomb and features amazing wind-up action!
And I've just realized she isn't the hero of the show...
I'll settle for the universe's most amazing chef Akito Tenkawa then, just because I found out an hour ago my Nadesico box set was probably lost in the mail and feel a need to cry. (The non-bootleg region 2 release of this series is exceedingly hard to track down in this anime-forsaken country I live in and has eluded me for the last four years.)