Shadow of the Collosus, though I've never beaten it, seing some of the giants, anthrpomorphic error gets the best of me. FF IX, first one I beat, had to re-play it, cause I was stuck at kuja (first real rpg, had no idea what I was doing), felt so good for them at the end. Mass Effect, though I never really got connected to the others in combat, I still felt for them, the whole planet where Ash and kaiden split up, the genophage, later, with the "non-vital staff" comment. In bioshock, the girl we see the ghost of, her betrayl, "you promised me prety, Steinmen!" The lady nursing the gun in the carriage in the very beginning. Prolly some others I'm missing.